Rowe & Wren
← Thyroid guide

TPO antibodies, in detail

Go deeper · 1 min 11 · No sound needed

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The film in words

TPO antibodies are raised in Hashimoto’s, and sometimes in Graves’ disease, an overactive thyroid: about 7 in 10 people with Graves’ disease have them.

In Hashimoto’s, TPO antibodies usually stay. Levels may fall over time, but hardly ever go back to normal, even once treatment has brought thyroid levels back to normal.

With a mildly underactive thyroid, antibodies can mean it may develop into full thyroid disease in future, but treatment isn’t needed yet.

In people without a thyroid disorder, TPO antibodies may be a marker of autoimmunity: autoimmune disease may be more likely in future.

Someone with autoimmune thyroid disease is more likely to develop another autoimmune condition, such as pernicious anaemia or coeliac disease, but the risk is still very small. Raise it with your doctor if new symptoms appear.

Source: British Thyroid Foundation: thyroid antibodies

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General information, not a diagnosis. Your GP can tell you what your results mean for you.